Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism
نویسندگان
چکیده
منابع مشابه
Surgical stress-mediated suppression of murine natural killer cell cytotoxicity.
Natural killer cell-mediated cytotoxicity (NKCC) is one of several possible immune defense mechanisms that may protect against the development of solid-tumor metastases. We have demonstrated that in vitro NKCC can be significantly impaired by both surgical stress and progressive tumor burden. Female C57BL/6 mice received a hindfoot amputation under anesthesia with Nembutal i.p. Twenty-four hr l...
متن کاملCell Cytotoxicity Surgical Stress-mediated Suppression of Murine Natural Killer
Natural killer cell-mediated cytotoxicity (NKCC) is one of sev eral possible immune defense mechanisms that may protect against the development of solid-tumor métastases. We have demonstrated that in vitro NKCC can be significantly impaired by both surgical stress and progressive tumor burden. Female C57BL/6 mice received a hindfoot amputation under anesthesia with Nembutal i.p. Twenty-four hr...
متن کاملEnhancement of natural killer cytotoxicity by cis-diamminedichloroplatinum (II) in vivo and in vitro.
To investigate the immunomodulating properties of cis-diamminedichloroplatinum (II) (CDDP), we studied the drug's effects on natural killer (NK) lymphocyte cytotoxicity. i.p. injections of CDDP (2-6 mg/kg) into adult mice significantly enhanced cytolysis of YAC-1 and K562 targets mediated by peritoneal and spleen cells. Lysis of the NK-resistant targets P815, EL-4, MOT, and RAJI was not increas...
متن کاملAugmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2
The possible beneficial effects of chronic low-dose irradiation (LDR) and its mechanism of action in a variety of pathophysiological processes such as cancer are a subject of intense investigation. While animal studies involving long-term exposure to LDR have yielded encouraging results, the influence of LDR at the cellular level has been less well defined. We reasoned that since natural killer...
متن کاملNatural Killer Cell Cytotoxicity Against SKOV3 after HLA-G Downregulation by shRNA
Background: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. Objective: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. Methods: The expression level of HLA-G was measured by real-time PCR and flowcytometry after transfec...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2001
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/22.4.599